monitoring and modelling of a continuous from-powder

Monitoring and modelling of a continuous from

Monitoring and modelling of a continuous from-powder-to-tablet process line Keywords: Continuous pharmaceutical production processes Control strategies Fluidized bed drying process Mass and energy balances Mechanistic models Monitoring SEVERINE THERESE F C MORTIER 1 2 INGMAR NOPENS 1 THOMAS DE BEER 2 KRIST V GERNAEY 3 * *Corresponding author 1

Case Studies from an Academic Perspective in Switching

In the second part of the presentation focus will be given to continuous from-powder-to-tablet manufacturing via continuous wet granulation In order to optimize and control continuous manufacturing through wet granulation increased process knowledge is needed which can be achieved by means of mechanistic modelling An overview will be given on modelling of both the wet

(569d) Process Monitoring of a Full Continuous

By using the on-line monitoring to support the implementation of real-time release in the production of pharmaceutics pharmaceutical companies does not have to wait anymore till the product is approved by the quality lab The ConsiGma TM (Collette TM GEA Pharma Systems Wommelgem Belgium) is a continuous from-powder-to-tablet manufacturing line intended for tablet production The continuous

Courses Offered by the MNS Department for Different

Continuous and Characteristic X-rays Bremsstrahlung Properties of X-rays X-ray technique Weissenberg and precession methods identification of crystal structure from powder photograph and diffraction traces Laue photograph for single crystal geometrical and physical factors affecting X-ray intensities analysis of amorphous solids and fibre textured crystal

Andre Schutte

• Plant optimisation and intelligent process parameter monitoring Show more Show less Section Engineer - Oxides/Recoveries Vanchem Vanadium Products (Division of Duferco Group) Aug 2013 – Jul 2015 2 years Witbank Area South Africa Vanchem Vanadium Products (Pty) Ltd is part of the international renowned Duferco Steel trading Group and produces various grades of vanadium

Crystal Nucleation Rates from Probability Distributions of

Monitoring the Dynamics of a Continuous Sonicated Tubular Cooling Crystallizer Microfluidics Setup Rapidly Measures Solubility Directly from Powder Organic Process Research Development 2018 22 (12) 1856-1860 DOI: 10 1021/acs oprd 8b00300 James F B Black Aurora J Cruz-Cabeza Roger J Davey Robert D Willacy Alvin Yeoh The Kinetic Story of Tailor-made Additives in

INHALATION EXPOSURE TO CARBON NANOTUBES (CNT)

Carbon nanotubes (CNT) and carbon nanofibers (CNF) are commonly used in commerce and applications are expected to increase in the near future (Zhao and Castranova 2011 De Volder et al 2013) Since approximately 2004 the U S Environmental Protection Agency (EPA) has reviewed over 60 notices for commercialization of these materials under Section 5 of the Toxic Substances Control Act

The next generation pharma skills you will need in view of

Modelling and simulation towards design space Definition Day 3 PAT for process monitoring and control of continuous manufacturing processes More Information Registration The Program for Download 2018-PharmaCourse-v1 pdf Adobe Acrobat Document 405 5 KB Download Share You might also like News Top drugs and pharmaceutical companies of 2019 by revenue Binder From powder

Pharmaceutical Applications of Chemometric Techniques

Chemometrics involves application of various statistical methods for drawing vital information from various manufacturing-related processes Multiway chemometric models like parallel factor analysis (PARAFAC) Tucker-3 N-partial least square (N-PLS) and bilinear models like principle component regression (PCR) and partial least squares (PLS) have been discussed in the paper

Pharmaceutics

In this study we established a robust feed-forward control model for the tableting process by partial least squares regression using the near-infrared (NIR) spectra and physical attributes of the granules to be compressed The NIR spectra of granules are rich in information about chemical attributes such as the compositions of any ingredients and moisture content

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13/09/2018The aim of this review is therefore to broaden the general understanding of how this technique can be used to complement and support AM which is not generally known and which is still under continuous development This includes various interesting applications and new developments applicable to AM at different levels from powder characterization to surface roughness assessment

INHALATION EXPOSURE TO CARBON NANOTUBES (CNT)

Carbon nanotubes (CNT) and carbon nanofibers (CNF) are commonly used in commerce and applications are expected to increase in the near future (Zhao and Castranova 2011 De Volder et al 2013) Since approximately 2004 the U S Environmental Protection Agency (EPA) has reviewed over 60 notices for commercialization of these materials under Section 5 of the Toxic Substances Control Act

2019 Abstracts – Fall Technical Conference

Several test cases from powder bed fusion AM systems will be discussed comparing post-build computed tomography (CT) scans of parts built under different conditions to output from in process monitoring (IPM) sensor systems implemented using the open-source tool suite DREAM 3D (Digital Representation Environment for Analysis of Microstructure in 3D) Challenges and lessons learned will

Scientific Facilities

The Stuttgart Center for Electron Microscopy (StEM) led by Peter A van Aken adds exceptional strength to the analytical capabilities of the Max Planck Institute for Solid State Research (MPI-FKF) StEM possesses outstanding expertise in the field of transmission electron microscopy (TEM) scanning electron microscopy (SEM) focused ion-beam (FIB) applications and methodology development

Andre Schutte

• Plant optimisation and intelligent process parameter monitoring Show more Show less Section Engineer - Oxides/Recoveries Vanchem Vanadium Products (Division of Duferco Group) Aug 2013 – Jul 2015 2 years Witbank Area South Africa Vanchem Vanadium Products (Pty) Ltd is part of the international renowned Duferco Steel trading Group and produces various grades of vanadium

QbD and PAT Topics at IFPAC 2014

19/01/2014Process Monitoring and Modeling of a Continuous Pharmaceutical from Powder to Tablet Process Line using a Mass Energy Balance Thomas De Beerb Severine Mortiera b Krist Gernaeyc Ingmar Nopensa aBIOMATH Department of Mathematical Modelling Statistics and Bioinformatics Faculty of Bioscience Engineering Ghent University Ghent Belgium bLaboratory of Pharmaceutical

Andre Schutte

• Plant optimisation and intelligent process parameter monitoring Show more Show less Section Engineer - Oxides/Recoveries Vanchem Vanadium Products (Division of Duferco Group) Aug 2013 – Jul 2015 2 years Witbank Area South Africa Vanchem Vanadium Products (Pty) Ltd is part of the international renowned Duferco Steel trading Group and produces various grades of vanadium

Structural Health Monitoring of Biocomposites Fibre

The main aim of SHM is to alert the system in initial stages of initiation of damage and avoid further propagation of failure with the help of continuous monitoring by structurally integrated sensors In general SHM is used to monitor the structure by measuring strain load displacement impact pH level moisture crack width vibration signatures and presence of cracks In SHM process

Effects of springback on the stretch forming of the

Changes of microstructure after physical modelling of conventional and normalising rolling of bars from carbon - manganese steel Stradomski G / Rydz D / Dyja H / Stradomski Z / Akademia Gomiczo-Hutnicza University of Birmingham University of Toyohashi | 2008 print version 208 Modelling microstructure evolution during hot rolling flat and long products of stainless steel Luo

Monitoring and modelling of a continuous from

The intention to shift from batch to continuous production processes within the pharmaceutical industry enhances the need to monitor and control the process in-line and real-time to continuously guarantee the end-product quality Mass and energy balances have been successfully applied to a drying process which is part of a continuous from-powder-to-tablet manufacturing line to calculate the

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manufacturing process development strategies and process monitoring and control methods will be presented As a first case study the development and potential use of a predictive platform for continuous direct compression processing through the use of extensive raw material databases will presented In the second part of the presentation focus will be given to continuous from-powder-to

Bruker

In this issue: Launch of the new S2 PUMA Series 2 C and S determination in cement with G4 ICARUS Series 2 getting the most from your SC-XRD instrument during COVID-19 lockdown EIGER2 R 500K upgrades for D8 ADVANCE and D8 DISCOVER lubricating oils by ASTM D6481 with S2 POLAR pharmaceutical structure solution from powder diffraction data quality control of limestone with S6

Prof Alastair Florence

determination from powder diffraction data and in-situ phase surveys using variable-temperature X-ray powder diffraction are key areas Representative Publications In Situ Monitoring of Stirring Effects on Polymorphic Transformations during Cooling Crystallization of Carbamazepine Crystal Growth Design 2012 12 4821-4828

Residual strain analysis in polycrystalline aggregates

A joined-up approach is used for assessing the deformation behaviour of polycrystalline materials at the macroscopic and grain levels based on combining modelling using the crystal plasticity finite element (CPFE) method with experimental characterization by in situ loading and continuous lattice strain measurement by diffraction The complementarity of the two methodologies is emphasized as

continuous scaling

Continuous Processing approach (which allows continuous production from [] powder to tablets in only 20 minutes) were particularly well received: the assurance of plug flow over the entire process and the increased number of measurements of critical quality attributes (CQA) which was confirmed by data from an uninterrupted 50-hour run resulting in 1 800 000 tablets